Friday, June 21, 2013

Mindfulness can increase wellbeing and reduce stress in school children

June 19, 2013 ? Mindfulness -- a mental training that develops sustained attention that can change the ways people think, act and feel -- could reduce symptoms of stress and depression and promote wellbeing among school children, according to a new study published online by the British Journal of Psychiatry.

With the summer exam season in full swing, school children are currently experiencing higher levels of stress than at any other time of year. The research showed that interventions to reduce stress in children have the biggest impact at this time of year. There is growing evidence that mindfulness-based approaches for adults are effective at enhancing mental health and wellbeing. However, very few controlled trials have evaluated their effectiveness among young people.

A team of researchers led by Professor Willem Kuyken from the University of Exeter, in association with the University of Oxford, the University of Cambridge and the Mindfulness in Schools Project, recruited 522 pupils, aged between 12 and 16 years, from 12 secondary schools to take part in the study. 256 pupils at six of the schools were taught the Mindfulness in Schools Project's curriculum, a nine week introduction to mindfulness designed for the classroom.

Richard Burnett who co-created the curriculum said: "Our mindfulness curriculum aims to engage even the most cynical of adolescent audience with the basics of mindfulness. We use striking visuals, film clips and activities to bring it to life without losing the expertise and integrity of classic mindfulness teaching."

The other 266 pupils at the other six schools did not receive the mindfulness lessons, and acted as a control group.

All the pupils were followed up after a three month period. The follow-up was timed to coincide with the summer exam period -- which is a potential time of high stress for young people. The researchers found that those children who participated in the mindfulness programme reported fewer depressive symptoms, lower stress and greater wellbeing than the young people in the control group. Encouragingly, around 80% of the young people said they continued using practices taught in MiSP's mindfulness curriculum after completing the nine week programme. Teachers and schools also rated the curriculum as worthwhile and very enjoyable to learn and teach.

Lead researcher Professor Kuyken said: "Our findings provide promising evidence of the effectiveness of MiSP's curriculum. We found that those young people who took part in the programme had fewer low-grade depressive symptoms, both immediately after completing the programme and at three-month follow-up. This is potentially a very important finding, given that low-grade depressive symptoms can impair a child's performance at school, and are also a risk factor for developing adolescent and adult depression."

Professor Katherine Weare, who has been instrumental in promoting the teaching of resilience in schools, said: "These findings are likely to be of great interest to our overstretched schools who are trying to find simple, cost effective and engaging ways to promote the resilience of their students -- and of their staff too -- at times when adolescence is becoming increasingly challenging, staff under considerable stress, and schools under a good deal of pressure to deliver on all fronts. This study demonstrates that mindfulness shows great promise in promoting wellbeing and reducing problems -- which is in line with our knowledge of how helpful well designed and implemented social and emotional learning can be. The next step is to carry out a randomised controlled trial into the MiSP curriculum, involving more schools, pupils and longer follow-ups."

Professor Felicia Huppert of the University of Cambridge said: "The findings also support the argument that mindfulness training can enhance the psychological well-being of all pupils, not just those who have symptoms associated with common mental health problems. Psychological well-being has been linked to better learning, social relationships and academic performance, so the enhancement of well-being is likely to improve a range of outcomes in the school context."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/lwUzNvwnw7I/130619195139.htm

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A Phone Full of Cheap Apps Is Your Deal of the Day

A Phone Full of Cheap Apps Is Your Deal of the Day

After the holiday season, early summer is the second best time to pick up some discounted digital games. Steam's summer sale is coming soon, but right now there are a ton of apps on sale for both iOS and Android, some of which are no-brainers, like the original Sonic The Hedgehog for $1. Actual smartphone not included.

Under "Top Deals" you'll find all the iOS and Android deals currently going on. If you've got an iDevice, you should definitely check out Infinity Blade 2: it's $1 today, down from $7, and it sports some of the nicest graphics you'll ever see on your iOS computer. If you've got an Android phone, maybe you want to check out SwiftKey, which is widely considered to be the best replacement Android keyboard. That's half off today, down to $2.

Unlike most app deals on Dealzmodo, today we're including all the apps on sale, not just the ones that went on sale in the last 24 hours, so this is as complete a list as you'll find. If we missed one, shout it out in the comments. Isn't it nice when a centralized app store and DRM actually makes games cheaper?

Top Deals

iOS

? Galaxy at War Online ($0) | iTunes via Appshopper | Originally $5

? Calendars+ ($0) | iTunes via 9to5Toys | Originally $7

? Infinity Blade II ($1) | iTunes via Appshopper | Originally $7

? Sonic The Hedgehog 4 ($1) | iTunes via Appshopper | Originally $5

? Sonic CD ($1) | iTunes via Appshopper | Originally $3

? Sonic The Hedgehog ($1) | iTunes via Appshopper | Originally $3

? Pocket RPG ($1) | iTunes via Appshopper | Originally $5

? Tuner + Metronome ($0) | iTunes via Appshopper | Originally $2

? Usagi Yojimbo ($0) | iTunes via Appshopper | Originally $2

? Random Heroes 2 ($0) | iTunes via Appshopper | Originally $1

? Kemco RPG Darkgate ($1) | iTunes via Appshopper | Originally $7

? Amazing Breaker ($0) | iTunes via Appshopper | Originally $1

? LetterLasso ($0) | iTunes via Appshopper | Originally $1

? Dream of Pixels ($1) | iTunes via Appshopper | Originally $3

? Feast or Famine ($0) | iTunes | Originally $1

? mPass Pro ($0) | iTunes via Appshopper | Originally $5

? Commando Jack ($0) | iTunes via Appshopper | Originally $1

iPad

? FREE Angry Birds Rio [iPad]

? Sonic the Hedgehog 4 Episode 1 HD ($1) | iTunes via Appshopper | Originally $4

Android

? Swiftkey Tablet ($2) | Google Play via App-sales | Originally $4

? Swiftkey ($2) | Google Play via App-sales | Originally $4

? Chaos Rings ($4.49) | Google Play via App-sales | Originally $9

? Chaos Rings Omega ($4.49) | Google Play via App-sales | Originally $9

? Final Fantasy III ($8) | Google Play via App-sales | Originally $15

? Chaos Rings II ($8) | Google Play via App-sales | Originally $16

? Broken Sword II: Smoking Mirror ($1) | Google Play via Ben's Bargains | Originally $5

? World War Z ($1) | Google Play via Apps-aholic | Originally $4

? Hero of Many ($2) | Google Play via Appsales | Originally $4

? Crystal Defenders ($4) | Google Play via Appsales | Originally $7

? Kainy ($1) | Google Play via Appsales | Originally $3

? Wordsmith ($1) | Google Play via Appsales | Originally $3

? Word Crack ($1) | Google Play via Appsales | Originally $3

Accessories

A Phone Full of Cheap Apps Is Your Deal of the Day

I swear, every time I buy one of these FM transmitters it's because I'm starting a road trip and I have no way to play music from my phone in the car. Because of my poor planning, I'm usually picking up a cheapo off-brand transmitter from a gas station for somewhere around $30. The smart move is to pick one up now, before you need it. [Groupon]

? Griffin iTrip FM Transmitter ($12) | Groupon via TechDealDigger | Originally $20

? Logitech T620 Touch Mouse ($20) | Staples via Ben's Bargains | Originally $30

? 2TB Seagate Expansion HD ($80) | Newegg via Dealmac | Originally $100

? $40 Staples Gift Card ($25) | Groupon via Deals Kinja | Save $15

? Wacom CTH670 Bamboo Create Pen Tablet ($100) | Tiger Direct via Deals Kinja | Lowest price ever after $80 rebate

? PNY Class 10 32GB SDHC Card ($23) | Best Buy via Deals Kinja | Today only

Miscellaneous

A Phone Full of Cheap Apps Is Your Deal of the Day

? iLaunch Thunder Missle Launcher ($30) | Groupon via Edealinfo | Originally $60, still $55 at Amazon

? Craftsman Bypass Pruner ($5) | Sears via Slickdeal | Originally $10 | I'm an anvil guy but these'll work too

? Cuisinart Ice Cream and Frozen Yogurt Maker ($35) | Sears via Deals Kinja | Factory refurbished, excellent reviews

? Lego City 4203 Excavator ($30) | Amazon via Ben's Bargains | Originally $50

? Philips Wake-Up Light ($56) | Amazon via Fatwallet | Originally $70

? Intel Core i5-4670K Haswell ($335) | Newegg via Ben's Bargains | Originally $400

? 50% off Dog Sitting | Amazon Local via Fatwallet

? $30 off $60 of Thinkgeek Exclusives | Thinkgeek | Use coupon code DROPCARGO

Gaming

PC

? Tomb Raider + FREE Hitman: Absolution [Steam] ($40) | Amazon

? FTL [Steam] ($5) | Amazon

? FREE with rebate Aliens: Colonial Marines| Newegg via TechBargains | Use codeEMCXPVX237

? Pre-order Rogue Legacy + Soundtrack [DRM Free/Steam] ($10) | Normally $15

PS3

? Max Payne 3 ($10) | Newegg via Daily Game Deals | Use code EMCXPVX246

? Metal Gear Solid Legacy Collection ($43) | Newegg via Daily Game Deals | Normally $50 | Use code EMCXPVX239

? Far Cry 3 ($20) | Amazon

Playstation 4 bundles, get your Playstation 4 bundles right here.
Xbox

? Far Cry 3 ($20) | Amazon

? Assassin's Creed 3 ($20) | Amazon

? Red Dead GOTY ($20) | Amazon via Daily Game Deals

Audio

? Yeti Pro USB Microphone ($160) | BuyDig via Dealmac | Originally $200 | Use coupon code PODPRO

? Pioneer Noise Cancelling Earbuds ($35) | Amazon via Deals Kinja | Lowest price ever

Clothing

Go naked.

Dumb TV ? Smart TV

? Mohu Leaf Ultimate Amplified Indoor Antenna ($50) | DealFisher via Cheapskate Blog | Originally $80

? Refurb Elgator EyeTV HD Video Recorder ($128) | Other World Computing via Dealmac | Originally $160

Physical Media

? 5 (Mediocre) Comic Book Movies on Blu-ray ($20) | Amazon via Brand Name Coupons | Originally $30

5 Mediocre comic movies? You mean 1 excellent comic movie, 1 pretty good comic movie, 1 mediocre comic movie, and 2 god awful comic movies. - Commenter CrapMcPoopin

? Sopranos Complete Series [DVD] ($125) | Amazon | Lowest price ever | What a classic show

Digital Media

George Orwell's masterpiece in Newspeak is $3 on Kindle and Google Play. [Deals Kinja]

? George Orwell's 1984 ($3) | Amazon or Google Play via Deals Kinja | Lowest price ever

Laptops

? AMD A6 Radeon HD 7500G Laptop from HP ($380) | Tiger Direct via Deals Kinja

Desktops

Sorry.

Tablets

No tablet deals, but hella tablet app deals up top.

Screens

A Phone Full of Cheap Apps Is Your Deal of the Day

This is a great deal on a 1080p Dell monitor.

? 23" Dell Monitor ($140) | Newegg via Hard Forum | Originally $190 | Use coupon code EMCXPVX45

Portables

Best Buy's doing their iPhone trade in program again. Basically, if you trade in an pristine iPhone 4S, you can save $150 off your next smartphone. I think that's a little low?I have an upgrade now but I'm passing on this deal?but I suspect it might be just the ticket for some folks.

? Verizon HTC Droid DNA w/ 2-Year Contract ($0) | Amazon via Fatwallet | Originally $200

? Verizon Palm Pixi ($38) | Ebay | Originally $80

Camera

? Pentax K-5 DSLR Body ($634) | BuyDig via Dealmac | Originally $800 | Use coupon code DIGTHEHEAT15

Bare Drives

? Samsung 840 250GB SSD ($160) | Newegg via Edealinfo | Originally $200

? Sandisk Ultra Plus 250GB SSD ($170) | Tiger Direct via Fatwallet | Originally $200 | MIR on page

Apps

iOS

See top.

Android

Ibid.

Hobomodo

Nothing in life is free.


Keep up with Kif Leswing on Kinja and Twitter. Check out The Moneysaver for more great tech deals, and deals.kinja.com for even more discounts.


A note on Dealzmodo: We're professional shoppers. Yes, we make money if you end up buying. That's capitalism, but we're absolutely looking out for your best interest. Read this if you want to know more.

Source: http://gizmodo.com/a-phone-full-of-cheap-apps-is-your-deal-of-the-day-519608361

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Dem senator presses Pentagon on Guantanamo feeding

(AP) ? The force-feeding of terror suspects at the U.S. detention facility at Guantanamo Bay, Cuba, runs counter to international standards, medical ethics and the practices at American prisons, the head of the Senate Intelligence Committee said Wednesday in pressing the Pentagon to establish a more humane treatment.

Sen. Dianne Feinstein, D-Calif., who traveled to Guantanamo earlier this month, wrote in a letter to Defense Secretary Chuck Hagel that she opposes the force-feeding of prisoners who have been on a hunger strike to protest their conditions and indefinite confinement.

As of Wednesday, 104 of the 166 prisoners at the U.S. detention facility were on hunger strike and 44 were being fed to prevent dangerous weight loss. One of the men was hospitalized for observation but did not have a life-threatening condition, said Army Lt. Col. Samuel House, a spokesman for the detention center on the U.S. base in Cuba.

"Hunger strikes are a long-known form of non-violent protest aimed at bringing attention to a cause, rather than an attempt of suicide," Feinstein wrote. "I believe that the current approach raises very important ethical questions and complicates the difficult situation regarding the continued indefinite detention at Guantanamo."

Feinstein said that during her June 7 visit to the installation with Sen. John McCain, R-Ariz., and White House Chief of Staff Denis McDonough, they were briefed on the Pentagon policies on handling prisoners on hunger strikes. Since then, a review by committee staff found significant differences between how the Pentagon force-feeds detainees at Guantanamo and how it is done by the U.S. Bureau of Prisons.

She said the U.S. prison system has several safeguards in place that do not exist at Guantanamo.

At Guantanamo, "all detainees being force-fed ? regardless of their level of cooperation ? are placed in chairs where they are forcibly restrained. The visual impression is one of restraint: of arms, legs, and body. Further, at Guantanamo Bay, detainees are fed twice a day in this manner, potentially over a substantial period of time."

After their trip, Feinstein and McCain issued a statement saying they favor closing the detention facility and moving the prisoners to other locations.

The defense bill approved by the Senate Armed Services Committee last week includes a provision that allows the temporary transfer of terror suspects to a Defense Department medical facility in the United States to prevent the death or significant imminent harm to a prisoner's health.

However, the full Senate is not expected to consider the bill until the fall and lawmakers are likely to try to change the provision.

___

Associated Press writer Ben Fox at the Guantanamo Bay Naval Base in Cuba contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-06-19-Guantanamo-Feinstein/id-49dca6b34db342098ae602e95c4a17c9

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Michael Hastings Dies in Car Accident; Acclaimed Journalist Was 33

Source: http://www.thehollywoodgossip.com/2013/06/michael-hastings-dies-in-car-accident-acclaimed-journalist-was-3/

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Thursday, June 20, 2013

Metadata Librarian, Rutgers University ? NJ | SLA New Jersey Chapter

The Rutgers University Libraries (RUL), Technical and Automated Services, seek an innovative, flexible, and energetic individual to serve as Metadata Librarian for Continuing Resources, Scholarship and Data, supporting the system-wide resource access needs of Rutgers University. This position is located on the New Brunswick Campus.

The individual will provide leadership, management, and strategic planning for bibliographic access to print and electronic continuing resources, scholarly papers and presentations, and research data in all formats, ensuring effective and accurate access to these resources in the library?s catalog, institutional repository and forthcoming webscale discovery layer environments. This position will provide metadata for resources in the scholarly information cycle, from research data to scholarly articles and published journals. The successful candidate will collaborate with library and academic faculty to describe and facilitate access to faculty publications and complex research data resulting from grants and other research activities, using the libraries? RUcore cyberinfrastructure. In consultation with other librarians and the Associate University Librarian (AUL), Digital Library Services, this position will:

  • Ensure effective and accurate access to print and electronic continuing resources utilizing AACR2/MARC and RDA, when locally implemented, in the library?s SirsiDynix catalog and forthcoming webscale discovery environment.
  • Work with library liaison faculty, academic faculty and others to understand the current and emerging needs of faculty for access, impact and reuse of scholarly and research resources in the RUcore repository.
  • Engage with library liaison faculty and RUcore managers and developers to design and implement tools, services and support new modes of scholarly communication , education and research at Rutgers University.
  • Develop application profiles and strategies to integrate continuing resources (e.g., journals, newspapers, yearbooks) into the Libraries? RUcore repository.
  • Define metadata requirements for research data and scholarly publications, establish application profiles and develop vocabularies to ensure a heavily used interdisciplinary institutional repository.
  • Collaborate with other metadata librarians to develop ontology services for a wide range of education and research needs.
  • Provide leadership and management to the Continuing Resources, Scholarship and Research Metadata unit of Central Technical Services, consisting of two full-time staff catalogers.
  • Participate in library committees, provide training and leadership within the department, and coordinate the provision of metadata services provided by departmental staff to a wide range of digital projects.
  • Remain abreast of current technologies and trends and represent the libraries in professional associations and at conferences in this area.

This tenure track faculty position reports to the AUL for Digital Library Systems, is a member of the Technical and Automated Services (TAS) library faculty, and will work closely in teams with the Centralized Technical Services and Scholarly Communication units. The successful candidate must demonstrate a commitment to scholarship through research, conference presentations, and publications. The individual must also demonstrate a commitment to continual professional development through participation in and leadership in the work of relevant professional associations and service to RUL and the university.

QUALIFICATIONS: An ALA-accredited MLS or its equivalent is required. A minimum of three years? library experience, including resource description; proven familiarity and direct experience with digital library collections and institutional repositories; knowledge of metadata standards such as AACR2, RDA, MODS, and Dublin Core required. The successful candidate must possess excellent written and verbal communication and interpersonal skills, and the ability to work collegially in a team-oriented environment. Successful experience in providing metadata description to a variety of digital resources, including scholarly publications, research data, and print and electronic continuing resources is strongly preferred. Supervisory or team management experience is preferred. Demonstrated commitment to fostering diversity is required. Candidates who have had successful experience in the design and delivery of services for diverse populations will be given preference. The successful candidate must be eligible to work in the United States.

SALARY/STATUS: Salary is commensurate with qualifications and experience.

BENEFITS: Faculty status, twelve-month appointment, retirement plan, life/health insurance, prescription drug, dental and vision plans, tuition remission, 22 vacation days annually.

LIBRARY PROFILE: The Rutgers University Libraries, comprising libraries on the University?s Camden, New Brunswick, and Newark campuses, all reporting to the Vice President for Information Services and University Librarian, operate as a unified library system with coordinated public, technical services, and collection development programs including digital initiatives and a pioneering institutional repository. The Libraries have highly valued staff of about 300
who are committed to developing innovations in access services, information literacy and digital initiatives. The Libraries operate with a budget of $28 million and outstanding collections especially in jazz and New Jerseyana. The Rutgers University Libraries are a member of ARL, CRL, Lyrasis, Metro, NERL, and VALE, and use Sirsi Dynix and OCLC as primary bibliographic utilities and Fedora repository software. In concert with the integration of the University of Medicine and Dentistry of New Jersey into Rutgers University, the libraries connected with those schools in Newark and New Brunswick will become part of the Rutgers University Libraries system as of July 1, 2013. The combined enrollment across all three campuses is more than 58,000 students from all 50 states and 125 countries working toward degrees in 28 schools and colleges with an overall emphasis on arts and sciences. The Rutgers University New Brunswick campus is the largest of the three regional campuses, supporting over 33,000 graduate and undergraduate students, in approximately 100 undergraduate programs, more than 80 graduate/professional programs, and 60 doctoral programs as a Carnegie Classification Research University (very high research activity) campus. Rutgers University is a member of the Association of American Universities and is an ADVANCE institution, committed to increase diversity and the participation and advancement of women in the STEM disciplines. Rutgers is also a member of the Committee on Institutional Cooperation (CIC), the nation?s premier higher education consortium of top tier research institutions, composed of members of the Big Ten Conference plus the University of Chicago.

TO APPLY:? REVIEW OF APPLICATIONS AND INTERVIEWS WILL BEGIN IMMEDIATELY AND CONTINUE UNTIL THE POSITION IS FILLED.? SUBMIT RESUME, COVER LETTER, NAMES OF THREE REFERENCES AND WHERE THE POSITION WAS ADVERTISED TO:

Lila Fredenburg (APP. 211), Director of Administrative Services
Rutgers University Libraries
169 College Avenue
New Brunswick, NJ 08901-1163
email: rulhr@rulmail.rutgers.edu
FAX: 732-932-7637

Rutgers, The State University of New Jersey, is an equal-opportunity, affirmative-action employer.? The Libraries are strongly and actively committed to diversity, and seek candidates who will contribute creatively to the University?s multicultural environment.

Written by: Darlene Davis on June 19, 2013.

Source: http://newjersey.sla.org/2013/06/19/metadata-librarian-rutgers-university-nj/

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Thursday, May 9, 2013

Soy and tomato may be effective in preventing prostate cancer

May 8, 2013 ? Tomatoes and soy foods may be more effective in preventing prostate cancer when they are eaten together than when either is eaten alone, said a University of Illinois study.

"In our study, we used mice that were genetically engineered to develop an aggressive form of prostate cancer. Even so, half the animals that had consumed tomato and soy had no cancerous lesions in the prostate at study's end. All mice in the control group -- no soy, no tomato -- developed the disease," said John Erdman, a U of I professor of food science and nutrition.

From the time they were 4 to 18 weeks old, the animals were fed one of four diets: (1) 10 percent whole tomato powder; (2) 2 percent soy germ; (3) tomato powder plus soy germ; and (4) a control group that ate neither tomato nor soy.

The 4- to 18-week time frame modeled an early and lifelong exposure to the bioactive components in these foods, he said.

"Eating tomato, soy, and the combination all significantly reduced prostate cancer incidence. But the combination gave us the best results. Only 45 percent of mice fed both foods developed the disease compared to 61 percent in the tomato group, and 66 percent in the soy group," he said.

Prostate cancer is the most frequently diagnosed cancer in men, but the disease has nearly a 100 percent survival rate if it's caught early. In older men, it is often a slow-growing cancer, and these men often choose watchful waiting over radiation and surgical treatments that have unwelcome side effects, said Krystle Zuniga, co-author of the paper.

Soy isoflavone serum and prostate levels in the mice are similar to those found in Asian men who consume one to two servings of soy daily. In countries where soy is eaten regularly, prostate cancer occurs at significantly lower levels, Erdman noted.

How much soy and tomato should a 55-year-old man concerned about prostate health eat in order to receive these benefits?

"The results of the mouse study suggest that three to four servings of tomato products per week and one to two servings of soy foods daily could protect against prostate cancer," Zuniga said.

According to the scientists, these findings reinforce the recommendation that we should all eat a wide variety of whole fruits and vegetables.

"It's better to eat a whole tomato than to take a lycopene supplement. It's better to drink soy milk than to take soy isoflavones. When you eat whole foods, you expose yourself to the entire array of cancer-fighting, bioactive components in these foods," Erdman said.

The researcher's whole-food recommendation is bolstered by the way soy germ performed in this study. He noted that soy germ has a very different isoflavone profile than the rest of the soybean.

"Of the isoflavones, genistein gets most of the attention. But soy germ is very high in the other isoflavones, daidzein and glycitein, and low in genistein," he said.

It was interesting for the scientists to see that the soy product they used, although low in genistein, was still very effective at reducing cancer incidence.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/nutrition/~3/j2xBda2yelI/130508114307.htm

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Gene test may help guide prostate cancer treatment

A new genetic test to gauge the aggressiveness of prostate cancer may help tens of thousands of men each year decide whether they need to treat their cancer right away or can safely monitor it.

The new test, which goes on sale Wednesday, joins another one that recently came on the market. Both analyze multiple genes in a biopsy sample and give a score for aggressiveness, similar to tests used now for certain breast and colon cancers.

Doctors say tests like these have the potential to curb a major problem in cancer care ? overtreatment. Prostate tumors usually grow so slowly they will never threaten a man's life, but some prove fatal and there is no reliable way now to tell which ones will. Treatment with surgery, radiation or hormone blockers isn't needed in most cases and can cause impotence or incontinence, yet most men are afraid to skip it.

"We're not giving patients enough information to make their decision," said Dr. Peter Carroll, chairman of urology at the University of California, San Francisco. "You can shop for a toaster" better than for prostate treatment, he said.

A study he led of the newest test ? the Oncotype DX Genomic Prostate Score ? is set for discussion Wednesday at an American Urological Association meeting in San Diego.

The results suggest the test could triple the number of men thought to be at such low risk for aggressive disease that monitoring is a clearly safe option. Conversely, the test also suggested some tumors were more aggressive than doctors had believed.

Independent experts say such a test is desperately needed but that it's unclear how much information this one adds or whether it will be enough to persuade men with low-risk tumors to forgo treatment, and treat it only if it gets worse. Only 10 percent who are candidates for monitoring choose it now.

"The question is, what's the magnitude of difference that would change the patient's mind?" said Dr. Bruce Roth, a cancer specialist at Washington University in St. Louis.

One man may view a 15 percent chance that his tumor is aggressive as low risk "but someone else might say, 'Oh my God, let's set the surgery up tomorrow,'" he said. "I don't think it's a slam dunk."

Also unknown: Will insurers pay for the expensive test without evidence it leads to better care or saves lives?

The newest test was developed by Genomic Health Inc., which has sold a similar one for breast cancer since 2004. Doctors at first were leery of it until studies in more groups of women proved its value, and the same may happen with the prostate test, said Dr. Len Lichtenfeld, the American Cancer Society's deputy chief medical officer.

The company will charge $3,820 for the prostate test and says it can save money by avoiding costlier, unnecessary treatment. Another test for assessing prostate cancer risk that came out last summer ? Prolaris by Myriad Genetics Inc. ? sells for $3,400.

Both companies can sell the tests without Food and Drug Administration approval under separate rules that govern lab diagnostics. Myriad Genetics has published nine studies on Prolaris involving more than 3,000 patients. Genomic Health has not published any results on the prostate test, another thing that makes doctors wary. Yet it has a track record from its breast cancer test.

About 240,000 men in the U.S. are diagnosed with prostate cancer each year, and about half are classified as low risk using current methods. Doctors now base risk estimates on factors such as a man's age and how aggressive cells look from biopsies that give 12 to 14 tissue samples. But tumors often are spread out and vary from one spot to the other.

"Unless you can be sure your biopsy has hit the most aggressive part that's in the prostate, you can't be sure" how accurate your risk estimate is, explained Dr. Eric Klein, chief of urology at the Cleveland Clinic, who led early development of the Oncotype prostate cancer test.

For one study, researchers used prostates removed from 440 men. They measured the activity of hundreds of genes thought to be involved in whether the cancer spread beyond the prostate or proved fatal. A second study of biopsies from 167 patients narrowed it down to 81 genes, and researchers picked 17 that seemed to predict aggressiveness no matter the location in the tumor.

A third study used single needle-biopsy samples from 395 UCSF patients scheduled to have their prostates removed. The gene test accurately predicted the aggressiveness of their cancer once doctors were able to see the whole prostate after surgery.

Using one current method, 37 of the 395 men would have been called very low risk and good candidates for monitoring. Adding the gene test put 100 men into that category, said another study leader, Dr. Matthew Cooperberg of UCSF. The gene test shifted about half of the men into either a lower or a higher risk category.

"It went both ways ? that was the remarkable thing. In any category of risk it added independent information compared to the standard criteria we use today," Carroll said. "More work needs to be done, but, in my opinion, this is a very good start."

However, Dr. Kevin McVary, chairman of urology at Southern Illinois University School of Medicine and a spokesman for the Urological Association, said the test must be validated in more men before it can be widely used.

"It's not there yet," he said.

UCSF just got a federal grant to see how men choose treatments and whether this test might sway them.

"We throw all these numbers at them. Are they really going to make a better decision?" Cooperberg said.

Dean Smith, 60, a retired marketing executive from Mill Valley, Calif., is following his doctor's advice to monitor the cancer he was diagnosed with in March. He said a gene test may have made him more comfortable with that decision.

At least six of his friends suffered side effects ranging from urinary leakage to inability to have sex after having their prostates removed.

"I would suspect that having cancer and having to live with it would be very difficult for them," but it doesn't bother him, Smith said. "I will die from something other than prostate cancer, I guarantee you."

___

Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP

Source: http://news.yahoo.com/gene-test-may-help-guide-prostate-cancer-treatment-041257399.html

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