Thursday, April 11, 2013

Young children have grammar and chimpanzees don't

Apr. 10, 2013 ? A new study from the University of Pennsylvania has shown that children as young as 2 understand basic grammar rules when they first learn to speak and are not simply imitating adults.

The study also applied the same statistical analysis on data from one of the most famous animal language-acquisition experiments -- Project Nim -- and showed that Nim Chimpsky, a chimpanzee who was taught sign language over the course of many years, never grasped rules like those in a 2-year-old's grammar.

The study was conducted by Charles Yang, a professor of linguistics in the School of Arts and Sciences and of computer science in the School of Engineering and Applied Science. It was published in the Proceedings of the National Academy of Sciences.

Linguists have long debated whether young children actually understand the grammar they are using or are simply memorizing and imitating adults. One of the difficulties in resolving this debate is the inherent limitations of the data; 2-year-old children have very small vocabularies and thus don't provide many different examples of grammar usage.

"While a child may not say very much, that doesn't mean that they don't know anything about language," Yang said, "Despite the superficial lack of diversity of speech patterns, if you study it carefully and formulate what having a grammar would entail within those limitations, even young children seem very much on target."

Yang's approach was to look at one area of grammar that young children do regularly display: article usage, or whether to put "a" or "the" before a noun. He found a sufficient number of examples of article usage in the nine data sets of child speech he analyzed, but there was another challenge in determining if these children understood the grammar rules they were using.

"When children use articles, they're pretty much error free from day one," Yang said. "But being error free could mean that they've learned the grammar of article usage in English, or they have memorized and are imitating adults who wouldn't make mistakes either."

To get around this problem, Yang took advantage of the fact that most nouns can be paired with either the definite or indefinite article to produce a grammatically correct phrase, but the resulting phrases have different meanings and usages. This makes the combinations vary in frequency.

For example, "the bathroom" is a more common phrase than "a bathroom," while "a bath" is more common than "the bath." This difference has nothing to do with grammar but rather the frequency with which phrases containing those combinations are used. There are simply more opportunities to use phrases like "I need to go to the bathroom" or "the dog needs a bath" than there are phrases like "there's a bathroom on the second floor" or "the bath was too cold."

This means that the likelihood of using a particular article with a given noun is not 50/50; it is weighted toward either "the" or "a." Such lopsided combination tendencies can be characterized by general statistical laws of language, which Yang used to develop a mathematical model for predicting the expected diversity of noun phrases in a sample of speech.

This model was able to differentiate between the expected diversity if children were using grammar, as compared to if they were simply imitating adults. Due to the differences of these frequencies, an adult might only say "the bathroom" -- never saying "a bathroom" -- to a child, but that child would still be able to say "a bathroom" if he or she understood the underlying grammar.

"When you compare what children should say if they follow grammar against what children do say, you find it to almost indistinguishable," Yang said. "If you simulate the expected diversity when a child is only repeating what adults say, it produces a diversity much lower than what children actually say."

As a comparison, Yang applied the same predictive models to the set of Nim Chimpsky's signed phrases, the only data set of spontaneous animal language usage publicly available. He found further evidence for what many scientists, including Nim's own trainers, have contended about Nim: that the sequences of signs Nim put together did not follow from rules like those in human language.

Nim's signs show significantly lower diversity than what is expected under a systematic grammar and were similar to the level expected with memorization.

This suggests that true language learning is -- so far -- a uniquely human trait, and that it is present very early in development.

"The idea that children are only imitating adults' language is very intuitive, so it's seen a revival over the last few years," Yang said. "But this is strong statistical evidence in favor of the idea that children actually know a lot about abstract grammar from an early age."

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The above story is reprinted from materials provided by University of Pennsylvania.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. C. Yang. Ontogeny and phylogeny of language. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1216803110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/Ked33y6puUA/130410131327.htm

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93% Zero Dark Thirty

All Critics (244) | Top Critics (45) | Fresh (229) | Rotten (17) | DVD (2)

What's striking is the absence of triumphalism -- Bigelow doesn't shy away from showing the victims shot down in cold blood in the compound -- and we come away with the overwhelming sense that this has been a grim, dark episode in our history.

This is an instant classic.

Chastain makes Maya as vivid as a bloodshot eye. Her porcelain skin, delicate features and feminine attire belie the steel within.

No doubt Zero Dark Thirty serves a function by airing America's dirty laundry about detainee and torture programs, but in its wake, there's a crying need for a compassionate Coming Home to counter its brutal Deer Hunter.

While "Zero Dark Thirty" may offer political and moral arguing points aplenty, as well as vicarious thrills,as a film it's simply too much of a passable thing.

From the very first scenes of Zero Dark Thirty, director Kathryn Bigelow demonstrates why she is such a formidable filmmaker, as adept with human emotion as with visceral, pulse-quickening action.

A film of infectious urgency, questionable accuracy, murky morality and undeniable emotional and intellectual power

Kathryn Bigelow's Zero Dark Thirty is a grueling masterpiece that captures the hunt for bin Laden with a daunting amount of realism and efficiency.

Slathered in controversy, Kathryn Bigelow's Zero Dark Thirty confidently and forcefully storms onto DVD with an admirable A/V transfer, only hindered by a paltry gathering of extras from Sony.

The direction by Kathryn Bigelow, who won Oscars for Best Film and Best Director in her previous film "The Hurt Locker," is fierce and focused...

Despite what those silly Oscars would have you believe, it was this movie, not Argo, that was the finest of 2012.

Indulges Cheneyian fantasies complete with the bad-movie scene of the prisoner's defiance: "You're just a garbage man in the corporation," shouts the Arab who needs a lesson in manners from the Ph.D. (in torture?) who is racking him.

Bigelow tells the story very well, very efficiently, but doesn't really say much about it, which is ironic given the response to the film in some quarters.

Kathryn Bigelow takes the procedural model and brushes away every unnecessary detail, leaving behind a heavy, blunt object of a film that is also hugely watchable, engrossing and, best of all... highly suspenseful.

Rotten Tomatoes notes that I agree with Tomatometer critics 80 percent of the time, but this is one of those times I have to part ways with them.

Bigelow has directed excellent movies before, but this deserves to be remembered as the film that established her as a master.

You can't deny that what Zero Dark Thirty sets out to do, it does excellently.

An exhilarating and compelling historical document worthy of praise.

Bigelow's latest proves a rewarding piece of filmmaking, one that, in its best moments at least, is as gripping and as troubling as anything the director's ever made.

Bigelow and screenwriter Mark Boal shape history -- those breaks, big and small, that led to the killing of Osama bin Laden -- into one of the finest fact-based thrillers since "All the President's Men."

Purely as cinematic exercise, Zero Dark Thirty is an exhilarating piece of work. But, beyond its for-the-times subject matter, the work does not linger whatsoever.

Zero Dark Thirty is interesting as opposed to enjoyable, intriguing as opposed to entertaining, and certainly less memorable than The Hurt Locker.

It's quite remarkable how Bigelow and Boal managed to take 12 years of information (including a conclusion that everyone knows) and packaged it into a coherent, intimate and intense movie.

We know the ending, yet remain mesmerized by familiar details, filmed with a harrowing sense of urgency. It's as close to being in the White House situation room that night, watching a closed-circuit broadcast, as anyone could expect.

The second half of the film IS the film.

Source: http://www.rottentomatoes.com/m/zero_dark_thirty/

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Trial of bin Laden's son-in-law set for January in New York City

BRUSSELS, April 8 (Reuters) - A French teenager who had hidden inside a garbage container was crushed to death inside a trash truck in Luxembourg on Saturday, police said. Garbage men only discovered the 17-year-old when he shouted out as they emptied the container into the back of the truck early on Saturday morning, but by then he was already in the grasp of the crushing mechanism. "He cried out, but it was already too late," a spokeswoman for Luxembourg police said on Monday. The young man, whose name was not released, died on the scene, in the city of Luxembourg. ...

Source: http://news.yahoo.com/trial-bin-ladens-son-law-set-january-york-215450299.html

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The relationship between prenatal stress and obesity is confirmed in rats

Wednesday, April 10, 2013

The intrauterine environment plays an important role in the health of the offspring. Now, experts from the University of Navarra affirm that the mother's stress, due to socio-economic or psycho-social causes, is associated with the development of pathologies related with obesity.

"The growing prevalence of obesity cannot be solely attributed to genetic factors or poor nutrition, but also to lifestyle and adverse environmental factors," as explained by Javier Campi?n, lead researcher of this new study. "The said environmental factors could have a bearing on epigenetic mechanisms, which are responsible for the control of genes beyond the genetic code itself".

For the authors, the fast pace which characterizes society produces an increase in stress rates within the population, and this rise, in parallel with the rates of obesity, makes an analysis of the interaction necessary between these two factors which do not only affect adult age groups.

The objective of the work, which was published in the magazine 'Stress', was to determine the effect on adult rats of moderate chronic stress during the final week's embryonic development on the phenotypical, biochemical and hormonal changes.

To do this the researchers studied two groups of rats, with and without stress, and examined in the offspring any alterations in the expression of genes related with obesity and the metabolism of glucocorticoids in the white adipose tissue.

"The general conclusion we obtained was that an adverse situation during intrauterine development could lead to animals, due to the ingestion of a hyper-calorific diet, experiencing a greater increase in body fat and biochemical, hormonal and genetic alterations," underlined Campi?n.

In addition the authors insisted that these changes at adult age induced by the ingestion of a diet rich in fat and sugars provoked obesity and other associated conditions, such as insulin resistance, the result of which is the development of type-2 diabetes.

Pregnancy in the 21st Century

"These days many women continue with their hectic lives during pregnancy almost up to the birth, without noticing the stress they may be under," the researcher indicated.

The experts allege that stress, which during the normal life of a woman may not affect health, could be altering the development of the baby and leading to a predisposition towards the development of pathologies during adulthood, possibly due to epigenetic modification. Every year, problems relating to obesity are responsible for over 2.8 million deaths throughout the world.

"A healthy life during the pregnancy does not only consist of a good diet, with a good provision of vitamins and minerals, but also in living a quiet life, without stress," Campi?n concluded.

###

FECYT - Spanish Foundation for Science and Technology: http://www.fecyt.es/fecyt/home.do

Thanks to FECYT - Spanish Foundation for Science and Technology for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127672/The_relationship_between_prenatal_stress_and_obesity_is_confirmed_in_rats

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Wednesday, April 10, 2013

Research holds revelations about an ancient society's water conservation, purification

Apr. 9, 2013 ? University of Cincinnati research at the ancient Maya site of Medicinal Trail in northwestern Belize is revealing how populations in more remote areas -- the hinterland societies -- built reservoirs to conserve water and turned to nature to purify their water supply. Jeffrey Brewer, a doctoral student in the University of Cincinnati's Department of Geography, will present his findings on April 11, at the Association of American Geographers' annual meeting in Los Angeles.

Brewer's research, titled "Hinterland Hydrology: Mapping the Medicinal Trail Community, Northwest Belize," continues a UC exploration of the ancient Maya civilization that has spanned decades. The site for Brewer's research, which was primarily occupied during the Classic Period (AD 250-900), functioned as a rural architectural community on the periphery of the major ancient Maya site of La Milpa.

Brewer says this smaller, remote settlement lacks the monumental architecture and population density typically associated with the major Maya sites, but shows similar, smaller-scale slopes, artificial terraces and water reservoirs that would have been utilized for farming and water management.

Brewer 's discovery of artificial reservoirs -- topographical depressions that were lined with clay to make a water-tight basin -- addressed how the Maya conserved water from the heavy rainfall from December to spring, which got them through the region's extreme dry spells that stretched from summer to winter. "They also controlled the vegetation directly around these reservoirs at this hinterland settlement," says Brewer. "The types of lily pads and water-borne plants found within these basins helped naturally purify the water. They knew this, and they managed the vegetation by these water sources that were used for six months when there was virtually no rainfall."

Without that system, Brewer says the smaller, more remote settlement would have been more dependent on the larger Maya sites that ran a larger water conservation system.

Brewer has conducted research at the site since 2006, including spending two years of intensive surveying and mapping of the region. Future research on the project will involve the completion of computerized mapping of up to 2,000 points of topography -- distances and elevations of the region in relation to water sources, population and structures. Brewer says he also wants to continue exploring the construction and management of these hinterland water systems and, if possible, gain a better understanding of what knowledge about them might have passed back and forth between settlements.

Funding for the research project was supported by the Charles Phelps Taft Research Center in the McMicken College of Arts and Sciences and UC International.

David M. Hyde, professor of anthropology at Western State Colorado University, was secondary researcher on the project.

The Association of American Geographers (AAG) is a nonprofit scientific and educational society that is dedicated to the advancement of geography. The annual meeting features more than 6,000 presentations, posters, workshops and field trips by leading scholars, experts and researchers in the fields of geography, environmental science and sustainability.

Brewer is presenting at a conference session that focuses on geospatial and geotechnical tools and methods that can be used to address questions of archaeological significance.

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The above story is reprinted from materials provided by University of Cincinnati. The original article was written by Dawn Fuller.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/mOiz00r2qa4/130409111605.htm

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McConnell aides secretly taped ripping Ashley Judd (cbsnews)

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Saturday, March 30, 2013

Cell reprogramming during liver regeneration

Friday, March 29, 2013

During embryonic development, animals generate many different types of cells, each with a distinct function and identity.

"Although the identities of these cells remain stable under normal conditions, some cells can be persuaded to take on new identities, through reprogramming," says Ben Stanger, MD, PhD, assistant professor of Medicine in the Division of Gastroenterology at the Perelman School of Medicine, University of Pennsylvania.

Researchers have been able to reprogram cells experimentally, but few have shown that cells can change their identities under normal physiological conditions in the body, particularly in mammals.

In the cover article of this month's issue of Genes and Development, Stanger, PhD candidate Kilangsungla Yanger, Yiwei Zong, PhD, and their colleagues, did just that in the liver of a mouse. Stanger is also an investigator in the Abramson Family Cancer Research Institute and the Department of Cell and Developmental Biology.

The adult liver contains two major cell types ? hepatocytes and biliary cells ? that differ dramatically in appearance and function. Hepatocytes are the main cell type in the liver, where they synthesize proteins and other macromolecules, and detoxify toxic substances. Biliary cells, on the other hand, line the bile ducts, which carry bile from the liver to the small intestine to help digest fats.

Using a sensitive method to tag and track how cells develop and differentiate, the researchers found that conditional expression of an activated Notch1 gene converted hepatocytes into biliary cells. Notch is an important receptor for relaying signals to tell cells how to develop.

What's more, after the researchers injured liver cells with a variety of toxins to stimulate wound healing, they found that over two to three weeks hepatocytes activated a biliary cell program on their own, acquiring the shape and function of biliary cells. These changes were dependent on the activation of endogenous Notch signaling.

"This is direct evidence that cells can be converted from one mature cell type to another in a live animal, as part of a normal response to injury," says Stanger. "We think that augmenting pre-existing cell reprogramming relationships may be another way to engineer cells for the treatment of diseases in which there are not enough bile ducts, such as cholestasis."

###

University of Pennsylvania School of Medicine: http://www.uphs.upenn.edu/news/

Thanks to University of Pennsylvania School of Medicine for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 70 time(s).

Source: http://www.labspaces.net/127525/Cell_reprogramming_during_liver_regeneration

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